Peptide Fragment Coupling via Continuous Flow Photochemical Rearrangement of Nitrones

Angewandte Chemie 52(15), 4251-4255, DOI: 10.1002/anie.201300504

Go with the flow: A general approach for amide bond formation by way of a continuous-flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl-alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20 minutes. A tetrapeptide was synthesized in this way and the method could be applied to peptide fragment coupling.