Nickel-Catalyzed Heck-Type Reactions of Benzyl Chlorides and Simple Olefins

Publication
Journal of the American Chemical Society 133(47), 19020-19023, DOI: 10.1021/ja209235d

Nickel-catalyzed intermolecular benzylation and heterobenzylation of unactivated alkenes to provide functionalized allylbenzene derivatives are described. A wide range of both the benzyl chloride and alkene coupling partners are tolerated. In contrast to analogous palladium-catalyzed variants of this process, all reactions described herein employ electronically unbiased aliphatic olefins (including ethylene), proceed at room temperature, and provide 1,1-disubstituted olefins over the more commonly observed 1,2-disubstituted olefins with very high selectivity.

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