Functionalized Templates for the Convergent Assembly of Polyethers: Synthesis of HIJK Rings of Gymnocin A

Angewandte Chemie 48(24), 4430-4432, DOI: 10.1002/anie.200900924

Extension ladder: The successful application of epoxide-opening strategies towards the synthesis of ladder-type polyethers is contingent upon further elaboration of the product. By employing two different functionalized templates, a fragment of gymnocin A that bears four sites for subsequent fragment coupling has been prepared (see scheme; Bn=benzyl).