Epoxide-Opening Cascades in Synthesis of Polycyclic Polyether Natural Products

Angewandte Chemie 48(29), 5250-5281, DOI: 10.1002/anie.200900600

The structural features of polycyclic polyether natural products can, in some cases, be traced to their biosynthetic origin. However in case that are less well understood, only biosynthetic pathways that feature dramatic, yet speculative, epoxide-opening cascades are proposed. We summarize how such epoxide-opening cascade reactions have been used in the synthesis of polycyclic polyethers (see scheme) and related natural products.