Direct beta-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis

Journal of the American Chemical Society 139(40), 13969-13972, DOI: 10.1021/jacs.7b05942

The direct β-selective hydrocarboxylation of styrenes under atmospheric pressure of CO2 has been developed using photoredox catalysis in continuous flow. The scope of this methodology was demonstrated with a range of functionalized terminal styrenes, as well as αsubstituted and β-substituted styrenes.