Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

Organic Letters 13(2), 280-283, DOI: 10.1021/ol1026848

A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.