Catalytic Addition of Simple Alkenes to Carbonyl Compounds Using Group 10 Metal Catalysts

Synlett (16), 2565-2582, DOI: 10.1055/s-0029-1217747

Recent advances using nickel complexes in the activation ofunactivated monosubstituted olefins for catalytic intermolecular carbon-carbon bond-forming reactions with carbonyl compounds, such as simple aldehydes, isocyanates, and conjugated aldehydes and ketones, are discussed. In these reactions, the olefins function as vinyl- and allylmetal equivalents, providing a new strategy for organic synthesis. Current limitations and the outlook for this new strategy are also discussed.