Timothy F. Jamison
Latest
- Multi-platform synthesis of ondansetron featuring process intensification in flow
- Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline
- Bayesian Optimization of Computer-Proposed Multistep Synthetic Routes on an Automated Robotic Flow Platform
- Synthesis of (±)-Emtricitabine and (±)-Lamivudine by Chlorotrimethylsilane–Sodium Iodide-Promoted Vorbrüggen Glycosylation
- Design of dynamic trajectories for efficient and data-rich exploration of flow reaction design spaces
- A Call for Increased Focus on Reproductive Health within Lab Safety Culture
- Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis
- Ready, Set, Flow! Automated Continuous Synthesis and Optimization
- Continuous flow strategies for using fluorinated greenhouse gases in fluoroalkylations,
- Continuous flow strategies for using fluorinated greenhouse gases in fluoroalkylations
- Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine
- Di-tert-butyl Phosphonate Route to the Antiviral Drug Tenofovir
- Continuous dimethyldioxirane generation for polymer epoxidation
- On-Demand Generation and Use in Continuous Synthesis of the Ambiphilic Nitrogen Source Chloramine
- A concise route to MK-4482 (EIDD-2801) from cytidine
- A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2
- Deuteriodifluoromethylation and gem-Difluoroalkenylation of Aldehydes Using ClCF2H in Continuous Flow
- Total Synthesis of (±)-Sceptrin
- A Scalable Membrane Pervaporation Approach for Continuous Flow Olefin Metathesis
- Continuous-Flow Synthesis of Tramadol from Cyclohexanone
- Monolithic Silica Support for Immobilized Catalysis in Continuous Flow
- Catalytic Generation and Use of Ketyl Radical from Unactivated Aliphatic Carbonyl Compounds
- Diazotization of S-Sulfonyl-cysteines
- Continuous Flow Synthesis of ACE Inhibitors From N-Substituted L-Alanine Derivatives
- Synthesis of the EFG Framework of Tamulamides A and B
- A Robotic Platform for Flow Synthesis of Organic Compounds Informed by AI Planning
- Modular Continuous Flow Synthesis of Imatinib and Analogues
- Total Synthesis of the Marine Ladder Polyether Gymnocin B
- Ni-Catalyzed Cross-Electrophile Coupling for the Synthesis of Skipped Polyenes
- Seven-Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification
- Automated On-Demand Titration of Organometallic Reagents in Continuous Flow,
- A Graph-Convolution Neural Network Model for the Prediction of Chemical Reactivity
- Using Carbon Dioxide as a Building Block in Continuous Flow Synthesis
- Synthesis of the ABC Framework of Tamulamides A and B
- Reconfigurable System for Automated Optimization of Diverse Chemical Reactions
- Bench-Stable Nickel Precatalysts with Heck-type Activation
- Continuous-Flow Chemistry in Undergraduate Education: Sustainable Conversion of Reclaimed Vegetable Oil into Biodiesel
- Xenoprotein Engineering via Synthetic Libraries
- Synthesis of Highly Substituted 2-Arylindoles via Copper-Catalyzed Coupling of Isocyanides and Arylboronic Acids
- Science of Synthesis: Flow Chemistry in Organic Synthesis
- 7-Step FlowSynthesis of the HIV Integrase Inhibitor Dolutegravir
- Bench-Stable N-Heterocyclic Carbene Nickel Precatalysts for C-C and C-N Bond-Forming Reactions
- Studies Toward Brevisulcenal F via Convergent Strategies for Marine Ladder Polyether Synthesis
- Ni-Catalyzed Electrochemical Decarboxylative C-C couplings in Batch and Continuous Flow
- Advaced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing
- Minimizing E-Factor in the Continuous-Flow Synthesis of Diazepam and Atropine
- Selective N- Monomethylation of Primary Anilines with Dimethyl Carbonate in Continuous Flow
- Photoredox Activation of Carbon Dioxide for Amino Acid Synthesis in Continuous Flow
- Direct beta-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis
- Synthesis and Utilization of Nitroalkyne Equivalents in Batch and Continuous Flow
- Flow-IEG Enables Programmable Thermodynamic Properties in Sequence-Defined Unimolecular Macromolecules
- A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow
- A Unified Continuous Flow Assembly Line Synthesis of Highly Substituted Pyrazoles and Pyrazolines
- Asymmetric Faradaic Systems for Selective Electrochemical Separations
- Enhanced Reaction Efficiency in Continuous Flow
- Electrochemically Mediated Reduction of Nitrosamines by Hemin-Functionalized Redox Electrodes
- Photoredox Activation of SF6 for Fluorination
- Anion-Selective Redox-Electrodes: Electrochemically-Mediated Separation with Heterogeneous Organometallic Interfaces
- Stereoselective Formation of Fully Substituted Ketone Enolates
- On-Demand Continuous Flow Production of Pharmaceuticals in a Compact, Reconfigurable System
- Iterative Exponential Growth of Stereo- and Sequence-Controlled Polymers
- Continuous Flow Synthesis and Purification of Atropine with Sequential In-Line Separations of Structurally Similar Impurities
- Scalable Synthesis of Sequence-Defined, Unimolecular Macromolecules by Flow-IEG
- Highly Regioselective Indoline Synthesis Under Nickel/Photoredox Dual Catalysis
- Rhodium-Catalyzed Endo-Selective Epoxide-Opening Cascades: Formal Synthesis of (−)-Brevisin
- Nickel Catalysis: Synergy Between Method Development and Total Synthesis
- A General Strategy for the Synthesis of Enantiomerically Pure Azetidines and Aziridines through Nickel-Catalyzed Cross-Coupling
- Hydroxyl-Substituted Ladder Polyethers via Selective Tandem Epoxidation/Cyclization Sequence
- Electophilic Amination: The Case of Nitrenoids
- A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing
- Synthesis of Highly Functionalized Polycyclic Quinoxaline Derivatives Using Visible-Light Photoredox Catalysis
- Continuous Flow Synthesis of Chiral Amines in Organic Solvents: Immobilization of E. coli Cells Containing Both ω-Transaminase and PLP
- Continuous Flow Total Synthesis of Rufinamide
- Highly Regioselective Nickel-Catalyzed Cross-Coupling of N-Tosylaziridines and Alkylzinc Reagents
- Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents
- Recent Advances in Homogeneous Nickel Catalysis
- A Broadly Applicable Strategy for Entry into Homogeneous Nickel(0) Catalysts from Air-Stable Nickel(II) Complexes
- Continuous-Flow Synthesis of Functionalized Phenols via Aerobic Oxidation of Grignard Reagents
- Microwave-Assisted Synthesis of Cyclic Carbonates from Olefins with Sodium Bicarbonate as the C1 Source
- Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical
- Mechanism-Guided Design of Flow Systems for Multicomponent Reactions: Conversion of CO2 and Olefins to Cyclic Carbonates
- Nickel-Catalyzed Mizoroki–Heck Reaction of Aryl Sulfonates and Chlorides with Electronically Unbiased Terminal Olefins: High Selectivity for Branched Products
- Bromine-Catalyzed Conversion of CO2 and Epoxides under Continuous Flow Conditions
- End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formulation
- Entropic Factors Provide Unusual Reactivity and Selectivity in Water-Promoted Epoxide-Opening Reactions
- A Reductive Coupling Strategy Toward Ripostatin A
- A Dioxane Template for Highly Selective Epoxy Alcohol Cyclizations
- End-to-End Continuous Flow Synthesis and Purification of Diphenhydramine Hydrochloride Featuring Atom Economy, In-Line Separation, and Flow of Molten Ammonium Salts
- Peptide Fragment Coupling via Continuous Flow Photochemical Rearrangement of Nitrones
- Hydrogen Free Alkene Reduction in Continuous Flow
- Simplifying Nickel(0) Catalysis: An Air-Stable Nickel Precatalyst for the Internally Selective Benzylation of Terminal Alkenes
- Continuous Flow Oxidation of Alcohols and Aldehydes Utilizing Bleach and Catalytic Tetrabutylammonium Bromide
- Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2’-Deoxy and 2’,3’-Dideoxynucleosides
- Continuous Flow Photocatalysis Enhanced Using an Aluminum Mirror: Rapid and Selective Synthesis of 2’-Deoxy and 2’,3’-Dideoxynucleosides
- Rapid Continuous Synthesis of 5′-Deoxyribonucleosides in Flow via Brønsted Acid Catalyzed Glycosylation
- A Continuous Homologation of Esters: An Efficient Telescoped Reduction–Olefination Sequence
- Visible-Light Photoredox Catalysis in Flow
- Scalable and Robust Synthesis of CpRu(MeCN)3PF6 via Continuous Flow Photochemistry
- Diisobutylaluminum Hydride Reductions Revitalized: A Fast, Robust, and Selective Continuous Flow System for Aldehyde Synthesis
- Mixing and Dispersion in Small-Scale Flow Systems
- Kinetic and Scale-Up Investigations of Epoxide Aminolysis in Microreactors at High Temperatures and Pressures
- Continuous Photochemical Generation of Catalytically Active [CpRu]+ Complexes from CpRu(η6-C6H6)PF6
- Nickel-Catalyzed Heck-Type Reactions of Benzyl Chlorides and Simple Olefins
- Ni(II) Salts and 2-Propanol Effect Catalytic Reductive Coupling of Epoxides and Alkynes
- Nickel-Catalyzed Allylic Substitution of Simple Alkenes
- Safe and Efficient Tetrazole Synthesis in a Continuous-Flow Microreactor
- Evidence that Epoxide-Opening Cascades Promoted by Water are Stepwise and Become Faster and More Selective After the First Cyclization
- Biomimetic Synthesis of Polyether Natural Products via Polyepoxide Opening
- Reductive Coupling and Cyclization of Carbon–Carbon Multiple Bonds
- Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
- Continuous Flow Multi-Step Organic Synthesis
- Amide Bond Formation via Reversible, Carboxylic Acid-Promoted Lactone Aminolysis
- Synthesis of Marine Polycyclic Polyethers via Endo-Selective Epoxide-Opening Cascades
- Ladder Polyether Synthesis via Epoxide-Opening Cascades Directed by a Disappearing Trimethylsilyl Group
- Aminolysis of Epoxides in a Microreactor System: A Continuous Flow Approach to Beta-Amino Alcohols
- Origins of Regioselectivity and Alkene-Directing Effects in Nickel-Catalyzed Reductive Couplings of Alkynes and Aldehydes
- Rhodium-Catalyzed Dehydrogenative Borylation of Cyclic Alkenes
- The Development of Endo-Selective Epoxide-Opening Cascades in Water
- Catalytic Addition of Simple Alkenes to Carbonyl Compounds Using Group 10 Metal Catalysts
- Total Synthesis of ent-Dioxepandehydrothyrsiferol via a Bromonium-Initiated Epoxide-Opening Cascade
- Epoxide-Opening Cascades in Synthesis of Polycyclic Polyether Natural Products
- Macrocyclization by Nickel-Catalyzed, Ester-Promoted, Epoxide-Alkyne Reductive Coupling: Total Synthesis of (-)-Gloeosporone
- Functionalized Templates for the Convergent Assembly of Polyethers: Synthesis of HIJK Rings of Gymnocin A
- Water Overcomes Methyl Group Directing Effects in Epoxide-Opening Cascades
- Mechanism and Transition-State Structures for Nickel-Catalyzed Reductive Alkyne−Aldehyde Coupling Reactions
- On the Synergism Between H2O and a Tetrahydropyran Template in the Regioselective Cyclization of an Epoxy Alcohol
- Strategic use of Nickel(0)-Catalyzed Enyne-Epoxide Reductive Coupling towards the Synthesis of (-)-Cyatha-3,12-diene
- SmI2-Promoted Reformatsky-Type Coupling Reactions in Exceptionally Hindered Contexts
- Alpha Olefins as Alkenylmetal Equivalents in Catalytic Conjugate Addition Reactions"
- Nickel-Catalyzed Coupling Reactions of Alkenes
- Total Synthesis of (+)-Acutiphycin
- Epoxide-Opening Cascades Promoted by Water
- Total Synthesis of Pumiliotoxins 209F and 251D via Late-Stage, Nickel-Catalyzed Epoxide-Alkyne Reductive Cyclization
- Regioselectivity and Enantioselectivity in Nickel-Catalysed Reductive Coupling Reactions of Alkynes
- Nickel-Catalyzed Synthesis of Acrylamides from alpha-Olefins and Isocyanates
- Highly Selective Coupling ofAlkenes and Aldehydes Catalyzed by NHC-Ni-P(OPh)3: Synergy Between a Strong σ-Donor and a Strong π-Acceptor
- Highly Convergent Total Synthesis of (+)-Acutiphycin
- Concerning Lewis Acid-Promoted, Directing Group-Free Epoxide Ring-Opening Cascades
- Nickel-Catalyzed Coupling of Alkenes, Aldehydes, and Silyl Triflates
- Directing Effects of Tethered Alkenes in Nickel-Catalyzed Coupling Reactions of 1,6-Enynes and Aldehydes
- Trans-Hydroalumination/Alkylation: One-Pot Synthesis of Trisubstituted Allylic Alcohols
- Nickel-Catalyzed, Carbonyl-Ene-Type Reactions: Selective for α Olefins and More Efficient with Electron-Rich Aldehydes
- Mechanistic Implications of Nickel-Catalyzed Reductive Coupling of Aldehydes and Chiral 1,6-Enynes
- Asymmetric Catalytic Reductive Coupling of 1,3-Enynes and Aromatic Aldehydes
- Simple Alkenes as Substitutes for Organometallic Reagents: Nickel-Catalyzed, Intermolecular Coupling of Aldehydes, Silyl Triflates, and Alpha Olefins
- A Comparative Analysis of the Total Syntheses of the Amphidinolide T Natural Products
- Synthesis of C13-C22 of Amphidinolide T2 via Nickel-Catalyzed Reductive Coupling of an Alkyne and a Terminal Epoxide
- Highly Regioselective, Catalytic Asymmetric Reductive Coupling of 1,3-Enynes and Ketones
- Anti-1,2-Diols via Ni-Catalyzed Reductive Coupling of Alkynes and α-Oxyaldehydes
- Enantioselective and Regioselective Nickel-Catalyzed Multicomponent Coupling of Chiral Allenes, Aromatic Aldehydes, and Silanes
- Highly Enantioselective and Regioselective Nickel-Catalyzed Coupling of Allenes, Aldehydes, and Silanes
- Total Syntheses of Amphidinolide T1 and T4 via Catalytic, Stereoselective Reductive Macrocyclizations
- Catalytic Reductive Coupling of Epoxides and Aldehydes: Epoxide Ring Opening Precedes Carbonyl Reduction
- Ligand-Switchable Directing Effects of Tethered Alkenes in Nickel-Catalyzed Additions to Alkynes
- Enantioselective Synthesis of (−)-Terpestacin and Structural Revision of Siccanol Using Catalytic Stereoselective Fragment Couplings and Macrocyclizations
- Asymmetric Catalytic Coupling of Organoboranes, Alkynes, and Imines Possessing a Removable (Trialkylsilyloxy)ethyl Group - Direct Access to Enantiomerically Pure Primary Allylic Amines
- Alkene-Directed, Nickel-Catalyzed Coupling Reactions of Alkynes
- Synthesis of Amphidinolide T1 via Catalytic, Stereoselective Macrocyclization
- Catalytic Reductive Carbon-Carbon Bond-Forming Reactions of Alkynes
- Synthesis of (−)-Terpestacin via Catalytic, Stereoselective Fragment Coupling: Siccanol is Terpestacin, not 11-epi-Terpestacin
- Nickel-Catalyzed Reductive Coupling of Alkynes and Epoxides
- Enantioselective Synthesis of Ladder Polyethers Using a Silicon-Assisted Homologation-Epoxidation-Cyclization Strategy
- Catalytic Three-Component Coupling of Alkynes, Imines, and Organoboron Reagents
- Catalytic Asymmetric Reductive Coupling of Alkynes and Aldehydes: Enantioselective Synthesis of Allylic Alcohols and α-Hydroxy Ketones
- Synthesis of Skipped Enynes via Phosphine-Promoted Coupling Reactions of Propargylcopper Reagents
- P-Chiral, Monodentate Ferrocenyl Phosphines, Novel Ligands for Asymmetric Catalysis
- Cobalt Cluster-Containing Carbonyl Ylides for Catalytic Three-Component Assembly of Oxygen Heterocycles
- Highly Selective Catalytic Intermolecular Reductive Coupling of Alkynes and Aldehydes,